产品详情
简单介绍：
ME0328,PARP-3Inhibitor
详情介绍：
Product Information
| Molecular Weight: | 321.37 |
| Formula: | C19H19N3O2 |
| Purity: | ≥98% |
| CAS#: | 1445251-22-8 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | (S)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
ME0328 is a potent, selective and cell permeable PARP-3 inhibitor with IC50 of 0.89 μM. It has good selectivity against PARP-1, PARP-2 and other ARDT enzymes. Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells.
How to Use:
In vitro: ME0328 was used at 10 µM in vitro and cellular assays.
In vivo: n/a
Reference:
- 1. Lindgren AE, et al. PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. (2013) ACS Chem Biol. 8(8):1698-703.
- 2. Wang H, et al. CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. (2017) Cancer Lett. 385:137-143.
- 3. Day TA, et al. PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. (2017) Nat Commun. 8:15110.
Products are for research use only. Not for human use.
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