| Molecular Weight: | 240.21 |
| Formula: | C14H8O4 |
| Purity: | ≥98% |
| CAS#: | 83280-65-3 |
| Solubility: | DMSO up to 20 mM |
| Chemical Name: | 2-acetylnaphtho[2,3-b]furan-4,9-dione |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
Napabucasin (BBI608) is a potent and selective STAT3 inhibitor. It can inhibit gene transcription driven by Stat3 and cancer stemness properties, can inhibit stemness gene expression and block spherogenesis of or kill stemness-high cancer cells isolated from a variety of cancer types (IC50 ~0.14-1.25 µM), but not hematopoietic stem cells. Napabucasin inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice.
How to Use:
In vitro: Napabucasin (BBI608) was used at 0.5-2 µM final concentration in various assays.
In vivo: Napabucasin (BBI608) can be dosed to mice at 50 mg/Kg by IP injection once per day in xenograft models.
Reference:
- 1. Li Y, et al. Suppression of cancer relapse and metastasis by inhibiting cancer stemness. （2015）Proc Natl Acad Sci USA. 112(6):1839-44.
Products are for research use only. Not for human use.
