| Molecular Weight: | 232.37 |
| Formula: | C6H4N2S4 |
| Purity: | ≥98% |
| CAS#: | n/a |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | 1,2-di(isothiazol-5-yl)disulfane |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
NU9056 is a potent and selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 are < 2 µM, 60 µM, 36 µM, and >100 μM for KAT5, p300, pCAF and GCN5, respectively), identified by a high-throughput screening. NU9056 inhibited cellular proliferation in a panel of prostate cancer cell lines (50% growth inhibition, 8-27 µM) and induced apoptosis via activation of caspase 3 and caspase 9 in a concentration- and time-dependent manner. The protein levels of androgen receptor, prostate specific antigen, p53 and p21 were decreased in response to treatment with NU9056. Furthermore, pre-treatment with NU9056 inhibited both ATM phosphorylation and Tip60 stabilization in response to ionizing radiation. NU9056 is a very useful chemical probe to study Tip60 (KAT5) histone acetyltransferase function.
How to Use:
- In vitro: NU9056 was used at 24 µM final concentration in vitro and in cellular assays.
- In vivo: n/a
Reference:
- 1. Coffey K, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. (2012) PLoS One. 7(10):e45539.
Products are for research use only. Not for human use.
