产品详情
简单介绍：
Pyrintegrin---CellSurvivalEnhancer
详情介绍：
Product Information
| Molecular Weight: | 451.54 |
| Formula: | C23H25N5O3S |
| Purity: | ≥98% |
| CAS#: | 1228445-38-2 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | N-(cyclopropylmethyl)-4-((4-(6-hydroxy-3,4-dihydroquinolin-1(2H)-yl)pyrimidin-2-yl)amino)benzenesulfonamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
Pyrintegrin is a cell-permeable small molecule that promotes human embryonic stem cell (hESC) survival by > 30-fold. Pyrintegrin can enhance cell-ECM adhesion-mediated integrin signaling. It can also stabilize the cell surface protein E-cadherin after cell dissociation.
How to Use:
- In vitro: Pyrintegrin was used at 3-5 µM concentration in cell culture.
- In vivo: n/a
Reference:
- 1. Xu Y, et al. Revealing a core signaling regulatory mechanism for pleuripotent stem cell survival and self-renewal by small molecules. (2010) PNAS 107(18): 8129-8134.
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