产品详情
简单介绍：
SKPinC1,Skp2Inhibitor
详情介绍：
Product Information
| Molecular Weight: | 465.34 |
| Formula: | C18H13BrN2O4S2 |
| Purity: | ≥98% |
| CAS#: | 432001-69-9 |
| Solubility: | DMSO up to 10 mM |
| Chemical Name: | (Z)-2-(4-bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
SKPin C1 is a potent and selective inhibitor of Skp2-mediated p27 degradation. It selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts. In cancer cells, the compounds induced p27 accumulation in a Skp2-dependent manner and promoted cell-type-specific blocks in the G1 or G2/M phases. SKPin C1 is a useful chemical probe selectively targeting SCF-Skp2 protein-protein interface, may provide a new avenue of cancer treatment with enhanced specificity over Bortezomib.
How to Use:
- In vitro: SKPin C1 was used at 10 µM final concentration in various in vitro assays.
- In vivo: n/a
Reference:
- 1. Wu L, et al. Specific small molecule inhibitors of Skp2-mediated p27 degradation. (2012) Chem Biol. 19(12):1515-24.
Products are for research use only. Not for human use.
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