产品详情
简单介绍：
Y-320---IL-17Immunomodulator
详情介绍：
Product Information
| Molecular Weight: | 505.01 |
| Formula: | C27H29ClN6O2 |
| Purity: | ≥98% |
| CAS#: | 288250-47-5 |
| Solubility: | DMSO up to 20 mM |
| Chemical Name: | 1-(4-chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
Y-320 is an orally active potent immunomodulator. It inhibits IL-15-induced IL-17 production by CD4 T cells with an IC50 of 20 nM. Therapeutic treatment with Y-320 (0.3 to 3 mg/kg orally) significantly inhibited the progression of arthritis and joint destruction in type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 inhibited the elevation of IL-17 mRNA expression in the joint of CIA mice. Concomitant treatment with Y-320 and anti-mouse TNF-alpha antibody showed a synergistic effect in mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys.
How to Use:
- In vitro: Y-320 was used at 0.1-1 µM final concentration in various in vitro assays.
- In vivo: Y-320 was administered orally at 0.3-3 mg/kg once day in mouse models.
Reference:
- 1. Ushio H, et al. A New Phenylpyrazoleanilide, Y-320, Inhibits Interleukin 17 Production and Ameliorates Collagen-Induced Arthritis in Mice and Cynomolgus Monkeys. (2013) Pharmaceuticals (Basel) 7(1), 1-17.
Products are for research use only. Not for human use.
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