| Purity: | Affinity purification |
| Storage: | Store at 4 or -20°C. Avoid freeze/thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
Catalog No: A70030
Histone H3R2me2s Polyclonal Antibody
Application:
WB (1:500-1:2000), IF (1:50-1:200), IP (1:50-1:200)
Cross-Reactivity:
H, M, R, other (wide range)
Calculated MW: 15kDa
Species: Rabbit
Isotype: IgG
Purity: Affinity purification
Concentration: 1mg/mL
Storage:
Store at 4 or -20°C. Avoid freeze/thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Immunogen Information
Immunogen:
A synthetic methylated peptide corresponding to residues surrounding Arg2 of human histone H3
Gene ID: 8290
Swiss Prot: Q16695
Synonyms:
HIST1H3J; H3/j; H3FJ; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/I; Histone H3/j; Histone H3/k; Histone H3/I; HIST3H3
Histone Arginine methylation is one of the most important epigenetic markers and is carried out by protein arginine methyltrasferase (PRMTs). Arginine residue can be either mono-methylated or symmetric/asymmetric dimethylated. Histone Arginine methylation/Demethylation involves in a variety of biological process. Recently studies include the finding that Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation (1) and the finding that symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance (2).
Reference:
1. Kirmizs A, et al. Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation. (2007) Nature (Impact Factor: 38.6) 449(7164): 928-32.
2. Yuan C, et al. Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes. (2012) Cell Rep. 1(2): 83-90
