产品详情
简单介绍：
OICR9429,WDR5Antagonist
详情介绍：
Product Information
| Molecular Weight: | 555.59 |
| Formula: | C29H32F3N5O3 |
| Purity: | ≥98% |
| CAS#: | n/a |
| Solubility: | DMSO up to 50 mM |
| Chemical Name: | N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
OICR9429 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist (Kd ~24-52 nM). It has >100-fold selectivity over other methyltransferases tested. It disrupts WDR5 interaction with peptide regions of MLL and Histone 3. OICR-9429 also disrupts the interaction of WDR5 with MLL1 and RbBP5 in cells with IC50 values below 1 µM.
How to Use:
In vitro: OICR9429 was used at 5-10 µM final concentration in various in vitro assays.
In vivo: n/a
Reference:
- 1. http://www.thesgc.org/chemical-probes/OICR-9429.
Products are for research use only. Not for human use.
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