产品详情
简单介绍：
1,4-DPCA,Prolyl4-hydroxylase(P4H)Inhibitor
详情介绍：
Product Information
| Molecular Weight: | 240.21 |
| Formula: | C13H8N2O3 |
| Purity: | ≥98% |
| CAS#: | 331830-20-7 |
| Solubility: | DMSO up to 10 mM, EtOH up to 20 mM |
| Chemical Name: | 4-oxo-1,4-dihydro-1,10-phenanthroline-3-carboxylic acid |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
1,4-DPCA is a selective and cell permeable prolyl 4-hydroxylase (P4H) inhibitor. It inhibits α-prolyl 4-hydroxylase, an oxygen-sensing enzyme that targets the pro-angiogenic factor HIF-1α for destruction upon hydroxylation of a specific proline residue. It also inhibits asparaginyl-hydroxylase factor inhibiting HIF (FIH) and is useful for controlling excess collagen deposition in pathological fibrosis.
How to Use:
In vitro: 1,4-DPCA was used at 10 µM final concentration in vitro and in cellular assays.
In vivo: n/a
Reference:
- 1. Jaakkola P, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. (2001) Science. 292(5516):468-72.
- 2. Franklin TJ, et al. Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones. (2001) Biochem J. 353(Pt 2):333-8.
- 3. Banerji B, et al. The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids. (2005) Chem Commun (Camb). (43):5438-40.
Products are for research use only. Not for human use.
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