产品详情
简单介绍：
GSK-LSD1,LSD1Inhibitor
详情介绍：
Product Information
| Molecular Weight: | 289.24 |
| Formula: | C14H22Cl2N2 |
| Purity: | ≥98% |
| CAS#: | 1431368-48-7 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine HCl salt |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
GSK-LSD1 is a highly potent, specific and irreversible inhibitor of Lysine Specific Demethylase-1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~16 nM, and is > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). GSK-LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM).
How to Use:
- In vitro: GSK-LSD1 was used at 1 µM in vitro.
- In vivo: n/a
Reference:
- 1. http://www.thesgc.org/chemical-probes/epigenetics
Products are for research use only. Not for human use.
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