产品详情
简单介绍：
IOX1,2OGOxygenasesInhibitor
详情介绍：
Product Information
| Molecular Weight: | 189.17 |
| Formula: | C10H7NO3 |
| Purity: | ≥98% |
| CAS#: | 5852-78-8 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | 8-hydroxyquinoline-5-carboxylic acid |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
IOX1 is a cell-permeable broad-spectrum inhibitor of most 2OG oxygenases. It inhibits histone demethylase JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX with IC50 at 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM respectively. IOX1 inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells.
How to Use:
- In vitro: IOX1 was used at 10-300 µM final concentration in various in vitro assays.
- In vivo: n/a
Reference:
- 1. King ON, et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. (2010) PLoS One. 5(11):e15535.
- 2. Schiller R, et al. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. (2014) ChemMedChem. 9(3):566-71.
- 3. http:// http://www.thesgc.org/chemical-probes/IOX1
Products are for research use only. Not for human use.
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