产品详情
简单介绍：
PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor
详情介绍：
Product Information
| Molecular Weight: | 499.52 |
| Formula: | C23H25F4N3O3S |
| Purity: | ≥98% |
| CAS#: | 1627676-59-8 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | (R)-8-fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 has been shown to bind to SETD7 by ITC (Kd=18nM), and biotinylated PFI-2 interacts with SETD7 in pull-down studies.
How to Use:
- In vitro: PFI-2 was used at 1 µM in vitro.
- In vivo: n/a
Reference:
- 1. http://www.thesgc.org/chemical-probes/epigenetics
Products are for research use only. Not for human use.
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