| Molecular Weight: | 466.53 |
| Formula: | C29H26N2O4 |
| Purity: | ≥98% |
| CAS#: | 947669-86-5 |
| Solubility: | DMSO up to 50 mM |
| Chemical Name: | ethyl 4'-((methyl(3-(pyridin-4-yl)benzyl)carbamoyl)oxy)-[1,1'-biphenyl]-4-carboxylate |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
WWL113 is a novel potent and selective inhibitor of Ces3 and Ces1f with IC50 ~0.1 µM in cellular assays. It was discovered by a high throughput screen. Carboxylesterase 3 (Ces3, also known as Ces1d) plays a key role in lipid metabolism (e.g., hydrolyzing long-chain fatty acid esters and thioesters) and promotes lipid storage in adipocytes. Ces3 activity is markedly elevated during adipocyte differentiation. Treatment of two mouse models of obesity/diabetes with WWL113 ameliorates multiple features of metabolic syndrome, including enhancing insulin sensitivity and glucose tolerance and reducing hepatic diacylglycerol species. WWL113 serves as a very useful chemical tool to pharmacologically validate Ces3 as a new therapeutic target.
How to Use:
- In vitro: WWL113 was used at 10 µM final concentration in various in vitro assays.
- In vivo: WWL113 was administered by oral dosing once a day at a dose of 30-50 mg/kg in the model of diet-induced obesity ordb/db mice.
Reference:
- 1. Dominguez E, et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. (2014) Nat Chem Biol. 10(2):113-21.
Products are for research use only. Not for human use.
