Introduction:
Primary mouse tail-tip fibroblasts (TTFs) are derived from ***** young mice. Under right condition, these cells can be cultured and maintained for 2-3 passages without senescence. PrimCells,LLC is proud to isolate and provide the primary cultures of TTFs from transgenic mice carrying IRES-GFP gene in their endogenous Pou5f1 (Oct4) locus. Oct4-GFP TTFs is used as a powerful tool for mechanistic study of somatic reprogramming due to their terminal differentiated state 1. When these cells are fully reprogrammed, iPSCs will become GFP+, which makes it easy to identify true iPSC clones and evaluate efficiency of different approaches. They are a great choice for your reprogramming researches.
Figure 1 | Successfully reprogrammed iPSCs become AP and GFP positive
PrimCells是位于美国加州圣迭戈的一家专业致力于细胞产品研发和解决方案提供的业内技术领导企业。 公司汇集了**的生物医药技术专家，独立开发了多项原代细胞和干细胞相关的专有技术。 公司以“细胞研究的选择”为宗旨，自主研发超过70种**产品，填补了多个特种细胞市场的空白。例如其诱导性表达细胞库和高效3D皮肤培养系统，皆为该类产品目前市场上少数的规模化供应商。此外，公司以高质量的数据与快速稳定的项目完成时间，长期为多家知名制药公司提供解决方案，获得用户广泛赞誉。 PrimCells产品线：
4. 人源重组蛋白 5. **型培养试剂 PrimCells 解决方案 1.诱导性稳定细胞株开发 2. 原代细胞开发 3. **体外毒理和效能测试 4. 3D-皮肤培养 PrimCells合作伙伴及客户: A．生物制药公司：辉瑞(Pfizer), 诺华(Novartis), 礼来(Eli2 Lilly),. Amgen, EMD Millipore, Regeneron等公司的毒理和医药研发部门 B．科研机构：冷泉港实验室，哈佛医学院, 麻省理工（MIT）,， UCSF, NYU, Salk, UIUC, USC等
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