别名：N-(2-(7-Methoxynaphth-1-yl)ethyl)acetamide/N-[2-(7-甲氧基萘-1-基)乙基]乙酰胺
英文名：Agomelatine
分子式：C15H17NO2
分子量： 243.3 纯度： >99% 外观：White or almost white powder
CAS No：138112-76-2 Biological Activity: Agomelatine is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways. Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant.