现货供应Temozolomide 替莫唑胺 C14235 上海佰世凯化学科技有限公司

现货供应Temozolomide/替莫唑胺

如果您对该产品感兴趣的话，可以
产品名称：现货供应Temozolomide/替莫唑胺
产品型号：C14235
产品展商：Chembest
产品文档：无相关文档

简单介绍

英文名：Temozolomide 分子式：C6H6N6O2 分子量： 194.15 外观： White to off-white crystalline powder 溶解性： Soluble in DMSO (20 mg/mL); slightly soluble in water 纯度： >99% CAS No： 85622-93-1

产品描述

英文名：Temozolomide
分子式：C6H6N6O2
分子量： 194.15
外观： White to off-white crystalline powder
溶解性： Soluble in DMSO (20 mg/mL); slightly soluble in water
纯度： >99%
CAS No： 85622-93-1

Biological Activity:

Temozolomide is an antitumor, antiangiogenic compound, that has been shown to work by alkylating DNA; typically through addition of a methyl group to guanine in genomic DNA. The efficacy of this compound is dependent on its ability to methylate the DNA, thus triggering apoptosis; however, some cells are able to repair this damage via the enzymes MGMT (O-6-methylguanine-DNA methyltransferase). As a consequence Temozolomide is far more efficacious in tumor cells that have silenced this repair enzyme. Research has also been conducted to determine whether MGMT inhibitors such as O-6-benzylguanine might help to increase the efficacy of Telozolomide. Furthermore, Temozolomide has been implicated in causing arrest at the G2-M cell cycle checkpoint, which might also play a role in its cytotoxicity

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

现货供应Temozolomide/替莫唑胺