现货供应Brefeldin C13399 上海佰世凯化学科技有限公司

现货供应Brefeldin A/布雷菲德菌素A

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产品名称：现货供应Brefeldin A/布雷菲德菌素A
产品型号：C13399
产品展商：Chembest
产品文档：无相关文档

简单介绍

别名：Ascotoxin, Decumbin, Cyanein 化学名称：1,6,7,8,9,11aβ,12,13,14,14αa-Decahydro-1β,13α-dihydroxy-6β-methyl-4H-cyclopent(f)oxacyclotridecin-4-one 英文名：Brefeldin A(BFA) 分子式：C16H24O 分子量： 280.36 纯度： 99% CAS N

产品描述

别名：Ascotoxin, Decumbin, Cyanein
化学名称：1,6,7,8,9,11aβ,12,13,14,14αa-Decahydro-1β,13α-dihydroxy-6β-methyl-4H-cyclopent(f)oxacyclotridecin-4-one
英文名：Brefeldin A(BFA)
分子式：C16H24O
分子量： 280.36
纯度： 99%
CAS No：20350-15-6

Biological Activity:

Inhibitor of intracellular protein transport and protein secretion, interfering with trafficking in the trans-Golgi network, leading to the accumulation of cycling proteins in ERGIC clusters. Blocks ADP-ribosylation factor (Arf) in an inactive GDP-bound conformation and thereby prevents binding of COPI coats to ERGIC and Golgi membranes. Upon brefeldin A treatment the Golgi rapidly tubulates and fuses with the ER by an energy-, temperature-, and microtubule-dependent process. In contrast, the drug has little effect on the ERGIC, which keeps its identity, although the ERGIC clusters become larger and more uniformly distributed in the cytoplasm of the cells.

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现货供应Brefeldin A/布雷菲德菌素A