Synonym: PD-0325901,MEK1/2 Inhibitor III Chemical Name: N-[((R)-2,3-Dihydroxypropyl)oxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide Molecular Formula: C16H14F3IN2O4 Molecular Weight: 482.19 Appearance: White solid Solubility: Soluble in ethanol, DMSO & methyl formamide Purity: >99% CAS No.： 391210-10-9 Biological Activity: PD0325901 is an orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation.