现货供应XAV 939 NVP-XAV939 C14349 上海佰世凯化学科技有限公司

现货供应XAV 939/NVP-XAV939

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产品名称：现货供应XAV 939/NVP-XAV939
产品型号：C14349
产品展商：Chembest
产品文档：无相关文档

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Chemical Name: 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol; 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one
别名：NVP-XAV939
分子式：C14H11F3N2OS
分子量：312.31
外观：White solid
纯度：>99%
CAS：284028-89-3
Biological Activity:
Tankyrase (TNKS) inhibitor, with IC50 values to be 11 and 4 nM for TNKS1 and TNKS2 respectively; inhibiting Wnt / β-catenin signaling; XAV939 is a cell-permeable small molecule inhibitor of the Wnt / β-catenin pathway that inhibits tankyrase 1 and tankyrase 2, thus stabilizing axin and stimulating β-catenin degradation; Current research suggests that Wnt proteins act to maintain stem cells in an undifferentiated, self-renewing state. Wnt proteins act on a variety of stem cells that include neural, mammary and embryonic stem cells. In addition, XAV939 inhibits growth of DLD-1 cells, an APC-deficient colorectal cancer cell line.

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现货供应XAV 939/NVP-XAV939