现货供应对照品Dovitinib C13587 上海佰世凯化学科技有限公司

现货供应对照品Dovitinib lactate(TKI258)/多韦替尼乳酸盐

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产品名称：现货供应对照品Dovitinib lactate(TKI258)/多韦替尼乳酸盐
产品型号：C13587
产品展商：Chembest
产品文档：无相关文档

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Chemical Name: 4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone 2-hydroxypropanoate hydrate (1:1:1)
别名：CHIR-258
英文名：Dovitinib lactate
分子式：C21H21FN6O.C3H6O3.H2O
分子量：500.53
外观：Brown crystal powder
纯度：>99%
CAS：915769-50-5
Biological Activity:
Dovitinib lactate is the orally bioavailable lactate salt of a benzimidazole-quinolinone compound with potential antineoplastic activity. Dovitinib strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. The activation of FGFR3 is associated with cell proliferation and survival in certain cancer cell types.

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现货供应对照品Dovitinib lactate(TKI258)/多韦替尼乳酸盐