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Entinostat(MS-275)
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Product Name:
Entinostat(MS-275)
Product Model:
C13619
Manufacturer:
E
file:
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Product Description
MS-275,SNDX-275#209783-80-2#C21H20N4O3#376.41#Soluble in DMSO at 25 mg/mL with slight warming; very poorly soluble in ethanol&water;#Off-white powder#>99%#500mg,1g,2g,5g#at -20℃ 2 years#MS-275 (Entinostat, SNDX-275, MS-27-275) is a potent HDAC inhibitor with IC50 of 0.3 and 8µM for HDAC1 and HDAC3, respectively.
Entinostat(MS-275)
Biological Activity:
MS-275 (Entinostat, SNDX-275, MS-27-275) is a potent HDAC inhibitor with IC50 of 0.3 and 8µM for HDAC1 and HDAC3, respectively. MS-275 (Entinostat, SNDX-275, MS-27-275) is synthetic benzamide derivative with potential antineoplastic activity. MS-275 (Entinostat, SNDX-275, MS-27-275) has no inhibitory activity towards HDAC8 (IC50>100 µM). MS-275 (Entinostat, SNDX-275, MS-27-275) appears to exert dose-dependent effects in human leukemia cells at low concentrations in human prostate cancer cell lines. MS-275 (Entinostat, SNDX-275, MS-27-275) exerted growth arrest in PC-3 and LNCaP cells, and induced cell death in DU-145 cells.
Entinostat(MS-275)
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