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Aurora Kinase Inhibitors
CETP inhibitor
HDAC
Proteases/HSP90/HSP70
Nuclear Receptors
Activators
PI3K/Akt/mTOR
Cytochrome P450
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7-TM Receptors
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Product Name/Model
Product Description
(+)-PD 128907 hydrochloride
C14371
(+)-PD 128907 hydrochloride#300576-59-4#C14H19NO3.HCl#285.77#Soluble to 10 mM in water#White solid#>99%#1g,2g,5g,10g#Desiccate at +4°C#Potent D3 dopamine receptor agonist (Ki = 2.3 nM).
(+)-Bicuculline
C10599
(+)-Bicuculline,d-Bicuculline#485-49-4#C20H17NO6#367.36#soluble in benzene,chloroform,ethyl acetate. Sparingly soluble in alcohol and ether#Pale yellow crystalline powder#>99%#1g,2g,5g#Store at -2#(+)-Bicuculline is an antagonist of the GABAA receptor.
Calcipotriol(MC 903)
C13426
MC 903#112965-21-6#C27H40O3#412.6#Soluble to 100 mM in DMSO and to 100 mM in ethanol#White powder#>99%#500mg/1g/2g/5g#Desiccate at -20°C#Vitamin D3 analog.
Calcifediol
C14395
25-Hydroxyvitamin D3, Calcidiol#19356-17-3#C27H44O2#400.64#Soluble in DMSO and in ethanol#Faint yellow powder#>99%#500mg/1g/2g/5g#Store at -20°C#Prohormone of calcitriol. Major circulating form of vitamin D.
Alfacalcidol
C13266
1-hydroxycholecalciferol#41294-56-8#C27H44O2#400.64#Soluble to 100 mM in DMSO and to 100 mM in ethanol#White solid#>99%#500mg/1g/2g/5g#Store at -20°C#Prodrug of vitamin D3.
Doxercalciferol
C13590
Doxercalciferol#54573-75-0#C28H44O2#412.65#Soluble to 50 mM in ethanol#White solid#>99%#100mg/250mg/500mg/1g#Desiccate at -20°C#Vitamin D2 analog, VDR agonist.
PSC 833(Valspodar)
C14314
SDZ-PSC-833,Amdray#121584-18-7#C63H111N11O12#1214.62#Soluble to 4 mM in DMSO#White solid#>98%#50mg,100mg#Store at -20°C#P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR).
AZD1152-HQPA(Barasertib)
C13349
Barasertib, AZD1152#722544-51 6#C26H30FN7O3#507.56#DMSO#Crystalline solid#>99%#100mg,200mg,500mg,1g,2g#at -20℃ 2 years# A potent and specific Aurora kinase B inhibitor
VX 680(MK 0457,Tozasertib)
C14340
Tozasertib,MK 0457#639089-54-6#C23H28N8OS#464.59#Soluble in DMSO;#White or pale yellow powder#>99%#500mg,1g,2g# -20°C#Potent inhibitor of aurora kinases with Ki values to be 0.6, 18 and 4.6 nM for auraro A, B and C isotypes respectively.
A 769662
C13240
A 769662#844499-71-4#C20H12N2O3S#360.39#Soluble in DMSO, slightly Soluble in ethanol#Off-white powder#>99%#500mg,1g,2g#Desiccate at -20°C#Potent, reversible AMP-activated protein kinase (AMPK) activator.
PP 121
C14043
PP 121#1092788-83-4#C17H17N7#319.36#Soluble in DMSO and ethanol# #>99%#500mg,1g,2g,5g#Store at +4°C#Dual kinase inhibitor; inhibits PI 3K family kinases.
GDC-0941, Free Base
C13707
GDC-0941#957054-30-7#C23H27N7O3S2#513.64#Soluble in DMSO at 66 mg/mL; very poorly soluble in ethanol&water;#White solid#>99%#100mg,500mg,1g,2g,5g#at -20℃ 2 years#GDC-0941 is an orally bioavailable bismesylate salt of a potent small-molecule thieno[3,2-d]pyrimidine inhibitor.
Torin 2
C14285
Torin 2#1223001-51-1#C24H15F3N4O#432.4#Soluble to 20 mM in DMSO#Yellow solid#>98%#500mg,1g,2g,5g#Store at +4°C#Potent and selective mTOR inhibitor (IC50 = 2.1 nM).
Torin 1
C14284
Torin 1#1222998-36-8#C35H28F3N5O2#607.62#Soluble to 1 mM in DMSO#Grey solid#>99%#500mg,1g,2g,5g#Store at +4°C#Potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2).
Brivanib alaninate(BMS-582664)
C13404
BMS-582664#649735-63-7#C22H24FN5O4#441.46#N/A#White solid#>99%##at -20 degree celsius 2 years#A novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor.
WZ4002
C14347
WZ-4002#213269-23-8#C25H27ClN6O3#494.18#Soluble in DMSO to 35 mM# #>99%#500mg,1g,2g,5g#at -20℃#WZ4002 is an EGFR T790M inhibitor(IC50<20nM).
AP24534(Ponatinib)
C14041
Ponatinib#943319-70-8#C29H27F3N6O#532.56#Soluble to 100 mM in DMSO and to 50 mM in ethanol#White powder#>99% #1g,2g,5g#Store at -20°C#Potent multi-kinase and pan-BCR-ABL inhibitor
Entinostat(MS-275)
C13619
MS-275,SNDX-275#209783-80-2#C21H20N4O3#376.41#Soluble in DMSO at 25 mg/mL with slight warming; very poorly soluble in ethanol&water;#Off-white powder#>99%#500mg,1g,2g,5g#at -20℃ 2 years#MS-275 (Entinostat, SNDX-275, MS-27-275) is a potent HDAC inhibitor with IC50 of 0.3 and 8µM for HDAC1 and HDAC3, respectively.
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