产品详情
简单介绍：
mKLF4 Lysate
详情介绍：
| Print Version | |
| Organism | Mouse |
| Accession # | Q60793 |
| Alias | Ezf, Gklf, Zie |
| Protein Type | Wild Type |
| Protein Sequence | MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRPAGAPTNRWREELSHMKRLPPLPGRPYDLAATVATDLESGGAGAACSSNNPALLARRETEEFNDLLDLDFILSNSLTHQESVAATVTTSASASSSSSPASSGPASAPSTCSFSYPIRAGGDPGVAASNTGGGLLYSRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLTTPGSEYSSPSVISVSKGSPDGSHPVVVAPYSGGPPRMCPKIKQEAVPSCTVSRSLEAHLSAGPQLSNGHRPNTHDFPLGRQLPTRTTPTLSPEELLNSRDCHPGLPLPPGFHPHPGPNYPPFLPDQMQSQVPSLHYQELMPPGSCLPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF |
| Protein Family | Belongs to the krueppel C2H2-type zinc-finger protein family. |
| Functions | Transcription factor which acts as both an activator and repressor. Binds the CACCC core sequence. Binds to multiple sites in the 5'-flanking region of its own gene and can activate its own transcription. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. KLF4 is one of the four factors in the Yamanaka protocol for iPSC reprogramming. The recombinant protein within the lysate has a 6X His tag at N-terminus for purification and 9X Arginine at C-terminus for cell membrane penetration. |
| Cell Types | Highest expression in the colon. Lower levels in testis, lung and small intestine. |
| Protein Location | Nucleus. |
| Tag | 6X His tag at N-terminus and 9X Poly-Arginine at C-terminus |
| Form | Liquid |
| Expression System | E.coli |
| Type | Lysate |
| Purification | None |
| Quality Control | By Western Blot Analysis |
| Concentration | 1mg/ml |
| Storage | DMEM with 2.5% glycerol |
| Shipping | On dry ice. |
| Notes | For Research Use Only, not for therapeutic or diagnostic purposes. |
| References | Induction of pluripotent stem cells from ***** human fibroblasts by defined factors. Takahashi et al. Cell. 2007 Nov 30;131(5):861-72. Induction of pluripotent stem cells from mouse embryonic and ***** fibroblast cultures by defined factors. Takahaski and Yamanaka. Cell. 2006 Aug 25;126(4):663-76. Epub 2006 Aug 10. |
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