产品详情
简单介绍：
Anti-Nestin Antibody
详情介绍：
| Overview | Print Version |
| Product Name | Anti-Nestin Antibody |
| Description | Nestin, is a large intermediate filament protein (class Type VI) that was first identified with a monoclonal antibody by Hockfield and McKay (1985). Nestin is expressed predominantly in stem cells of the central nervous system in the neural tube. Nestin is expressed during development and in myotendinous and neuromuscular junctions. Nestin expression is restricted, typically disappearing by E18. Nestin is thought to be a reasonable neuronal marker; however, recent studies have found nestin expression in other cell types such as endothelial cells. Nestin expression is seen in almost all GBMs (Glioblastoma mulitformes) and many melanomas (both primary and metastatic) but not in any metastatic carcinomas. Upon terminal neural differentiation, nestin is downregulated and replaced by neurofilaments. |
| Subtype | polyclonal |
| Application | WB, ELISA, Other, |
| Raised In | Rabbit |
| Specificity | This affinity purified antibody is directed against human Nestin protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross reactivity with Nestin protein from human and macaque (100% homology). Based on protein sequence homology also expect partial reactivity against Nestin homologues from rabbit (94%), mouse (reactivity shown above), rat and hamster (88%), and bovine and dog (82%). Reactivity against homologues from other sources is not known. |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to amino acids 1484-1500 of human Nestin protein. |
| Guarantee | abm guarantees that all our Anti-Nestin Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Properties | |
| Formulation | Liquid |
| Quantity | 100 μg |
| Clone | Polyclonal |
| Storage | This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Storage Buffer | PBS, pH 7.4 with 0.05% sodium azide. |
| Concentration | 1µg/ul |
| Purity | Affinity Purified |
| Isotype | IgG |
| Species Reactivity | human, rat, other |
| Anti-Nestin Antibody Images | |
|
|
| Specific References | |
|
Y050405 has been referenced in 1 publication.
|
|
相关文章
