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VX 680(MK 0457,Tozasertib)
]
Product Name:
VX 680(MK 0457,Tozasertib)
Product Model:
C14340
Manufacturer:
V
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Product Description
Tozasertib,MK 0457#639089-54-6#C23H28N8OS#464.59#Soluble in DMSO;#White or pale yellow powder#>99%#500mg,1g,2g#
-20°C#Potent inhibitor of aurora kinases with Ki values to be 0.6, 18 and 4.6 nM for auraro A, B and C isotypes respectively.
VX 680(MK 0457,Tozasertib)
Chemical name:N-[4-[4-(4-Methylpiperazin-1-yl)-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-sulfanyl]phenyl]- cyclopropanecarboxamide
Biological Activity:
Potent inhibitor of aurora kinases with Ki values to be 0.6, 18 and 4.6 nM for auraro A, B and C isotypes respectively; inhibiting also ABL (Ki=30 nM) and FLT3 (Ki=30 nM) kinases.
VX 680(MK 0457,Tozasertib)
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