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AP24534(Ponatinib)
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Product Name:
AP24534(Ponatinib)
Product Model:
C14041
Manufacturer:
A
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Product Description
Ponatinib#943319-70-8#C29H27F3N6O#532.56#Soluble to 100 mM in DMSO and to 50 mM in ethanol#White powder#>99%
#1g,2g,5g#Store at -20°C#Potent multi-kinase and pan-BCR-ABL inhibitor
AP24534(Ponatinib)
Alternative Name: Ponatinib
Chemical Name: 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide
Biological Activity
Potent multi-kinase and pan-BCR-ABL inhibitor. Displays potent activity against cell lines expressing native BCR-ABL or BCR-ABLT3151 (IC50 values are 0.37 and 2.0 nM respectively); also inhibits other ABL kinase domain mutants at nanomolar potencies. Exhibits inhibitory activity against PDGFRα, c-Src and c-Kit (IC50 values are 1.1, 5.4 and 12.5 nM respectively); potently inhibits FGFR and VEGFR family kinases. Orally active.
AP24534(Ponatinib)
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