猪胰岛素单克隆抗体
规格：1mg/1ml
英文名： Insulin(1D4:)
别名： ILPR; INS; Insulin A chain; Insulin B chain; Insulin precursor; IRDN; Proinsulin; Proinsulin precursor.
分子量： 5.8/12kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Monoclonal
亚型：IgG
纯化方法：affinity purified by Protein G
**原：Insulin from porcine pancreas
交叉反应：Human, Pig,
猪胰岛素单克隆抗体细胞定位：分泌型蛋白
产品介绍：background: Insulin is a pancreatic hormone that regulates glucose and is involved in the synthesis of protein and fat. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds.Belongs to the insulin family. The insulin-link growth factors, IGF-I and IGF-II (also desinated somatomedin C and multiplication stimulating activator, respectvely), share approximatly 76% sequence identity and are 50% related to pro-insulin.IGF-I and IGF-II are nonglycosylated, single chain proteins of 70 and 76 amino acids in length, respectivelly. IGF-I functions as an autocrine regulator of growth in vaious, whereas the function of IGF-II is less well defined. Function: Insulin decreases blood glucose concentration.猪胰岛素单克隆抗体 It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Subunit: Heterodimer of a B chain and an A chain linked by two disulfide bonds. Subcellular Location: Secreted. DISEASE: Hyperproinsulinemia, familial (FHPRI) [MIM:176730]: An autosomal dominant condition characterized by elevated levels of serum proinsulin-like material. Note=The disease is caused by mutations affecting the gene represented in this entry. Diabetes mellitus, insulin-dependent, 2 (IDDM2) [MIM:125852]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Note=The disease is caused by mutations affecting the gene represented in this entry. Diabetes mellitus, permanent neonatal (PNDM) [MIM:606176]: A rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal 猪胰岛素单克隆抗体diabetes requires lifelong therapy. Note=The disease is caused by mutations affecting the gene represented in this entry. Maturity-onset diabetes of the young 10 (MODY10) [MIM:613370]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early *****hood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the insulin family. Gene ID: 397415 Database links: Entrez Gene: 3630 Human Entrez Gene: 280829 Cow Entrez Gene: 16333 Mouse Entrez Gene: 16334 Mouse Entrez Gene: 24505 Rat Entrez Gene: 397415 Pig Omim: 176730 Human SwissProt: P01308 Human SwissProt: P01325 Mouse SwissProt: P01322 Rat SwissProt: P01315 Pig Unigene: 272259 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胰岛素（Isulin）是胰岛细胞分泌的一种**，可以降低血糖浓度。此抗体和人胰岛素反应，并与大多数哺乳类动物的胰岛素有交叉反应，主要用于胰岛细胞瘤的功能性研究。
猪胰岛素单克隆抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 神经生物学 信号转导 生长因子和** 糖尿病 ***病 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Mouse