人乙型肝炎表面抗原单克隆抗体
规格：1mg/1ml
英文名： HBsAg(H2F4)
别名： Hepatitis B Virus Surface Antigen; HBsAg; HBV major surface antigen; HBV surface antigen; Hepatitis B Virus major surface antigen; Major surface antigen; S; HBSAG_HBVC5.
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Monoclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：Human Hepatitis B Surface Antigen protein
交叉反应：HBsAg
人乙型肝炎表面抗原单克隆抗体细胞定位：细胞膜
产品介绍：background: Hepatitis B Virus Surface Antigen, Hepatitis B Virus (HBV) infection induces a disease state characterised by liver damage, inflammation and viral persistence. Infection also increases the risk of hepatocellular carcinoma. HBV belongs to the Hepadnaviridae family of viruses. Its genome consists of partially double stranded circular DNA. The DNA is enclosed in a nucleocapsid, or core antigen (HBcAg), which is surrounded by a spherical envelope (surface antigen or HBsAg). The core antigen shares its sequences with the e antigen (HBeAg) but no cross reactivity between the two proteins has been observed. The HBV genome also encodes a DNA polymerase that also acts as a reverse transcriptase. Function: The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. 人乙型肝炎表面抗原单克隆抗体The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein. The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid. Subunit: Li-HBsAg interacts with capsid protein and with HDV Large delta antigen. Isoform M associates with host chaperone CANX through its pre-S2 N glycan. This association may be essential for M proper secretion. Subcellular Location: Virion membrane. Post-translational modifications: Isoform M is N-terminaly acetylated at a ratio of 90%, and N-glycosylated at the pre-S2 region. Myristoylated. Similarity: Belongs to the orthohepadnavirus major surface antigen family. 人乙型肝炎表面抗原单克隆抗体Gene ID: 944569 Database links: Entrez Gene: 2828293 Hepatitis B virus Entrez Gene: 944569 Hepatitis B virus SwissProt: P03138 Hepatitis B virus SwissProt: P03140 Hepatitis B virus SwissProt: P03141 Hepatitis B virus SwissProt: Q81157 Hepatitis B virus SwissProt: Q81158 Hepatitis B virus SwissProt: Q81159 Hepatitis B virus SwissProt: Q81160 Hepatitis B virus Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 人乙型肝炎表面抗原抗体
人乙型肝炎表面抗原单克隆抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 **及病毒
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Mouse