**肽/天蚕**肽单克隆抗体
规格:1mg/1ml
英文名: Cecropin
别名: attacin.
分子量: 4kDa
储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型:Monoclonal
亚型:IgG
纯化方法:affinity purified by Protein A
**原:KLH conjugated synthetic peptide derived from Hyalophora cec
交叉反应:Hyalophora cecropia
**肽/天蚕**肽单克隆抗体细胞定位:
产品介绍:background: No data available. Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria. Subcellular Location: Secreted. Post-translational modifications: A protein with the same sequence as cecropin A, but lacking the carboxyl blocking group, has been isolated and called cecropin C (PubMed:7140755). Similarity: Belongs to the cecropin family. Database links: **肽/天蚕**肽单克隆抗体GenBank: AAP93872.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 天蚕素(cecropins)是**个被发现的动物**肽,1980年,由Boman等从天蚕蛹中分离得到。该类多肽***一般含有37~39个氨基酸残基,不含半胱氨酸,其N端区域具有强碱性,可形成近乎**的双亲螺旋结构,而在C端区域可形成疏水螺旋,两者之间有甘氨酸和脯氨酸形成的铰链区,多数多肽的C端被酰胺化,酰胺化对其**活性具有重要作用。天蚕素(cecropins)对革兰氏阳性菌、部分革兰氏阴性菌具有很强的杀伤力,而对**和真核细胞没有毒性。目前研究认为,**肽是*具潜力的***替代品之一。而天蚕素又是目前研究比较清楚的**肽。 **肽/天蚕**肽单克隆抗体 天蚕素**肽利用N端所带的正电荷与原核细胞的细胞膜磷脂双分子层密集的负电荷静电相吸,C端柔性的插入疏水区,在两亲性α-螺旋作用下,在原核细胞膜上形成4nm的离子通道,离子通道的形成改变了细胞膜内外的渗透压,细胞膜内物质大量外渗,致**细胞死亡,起到**作用。天蚕素**肽对**、病毒、***、原虫、癌细胞具有广谱的活性,能抑制革兰氏阳性和阴性球菌和杆菌,如绿脓杆菌、大肠杆菌、伤寒杆菌、痢疾杆菌、布氏杆菌、金黄色葡萄球菌、溶血性链球菌等等,并对感染植物的多种病原菌也有明显的**作用。另外,天蚕素**肽对高度耐药的伤寒杆菌、耐药性金葡菌同样敏感,对感冒、疤疹病毒能抑制其繁殖,对疟原虫、痢疾阿米巴均有效
**肽/天蚕**肽单克隆抗体产品应用:ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域:**学
储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源: Mouse
外观: Lyophilized or Liquid