畸胎瘤衍化生长因子单克隆抗体
规格：1mg/1ml
英文名： CRIPTO
别名： CRIPTO; CRIPT; CR; CRGF; Cripto 1; Cripto-1; Cripto 1 growth factor; Cripto-1 growth factor; Cripto1; Cripto1 growth factor; Epidermal growth factor like cripto protein CR1; Epidermal growth factor-li
分子量： 13kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Monoclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Teratoca
交叉反应：Human, Mouse, Rat,
畸胎瘤衍化生长因子单克隆抗体细胞定位：细胞膜
产品介绍：background: This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. Function: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Subunit: Interacts with the activin type-1 receptor ACVR1B. Subcellular Location: Cell membrane;畸胎瘤衍化生长因子单克隆抗体 Lipid-anchor, GPI-anchor. Tissue Specificity: Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung. Similarity: Contains 1 EGF-like domain. Database links: NCBI Reference Sequence: NP_003203.1 UniProtKB/Swiss-Prot: P13385.1 Important Note: This product as supplied is intended for research use only, not for use in 畸胎瘤衍化生长因子单克隆抗体human, therapeutic or diagnostic applications. Cripto-1是表皮生长因子-Cripto-FRL-Criptic(EGF-CFC)家族成员之一, 属于转化生长细胞TGF-β蛋白家族及Nodal蛋白质的共同受体。Cripto蛋白对于胚胎的发育占有非常重要的地位。 Cripto-1在人类的多种肿瘤如结肠癌、乳腺癌、卵巢癌、胰腺癌等中高表达，可激活P13K/Akt/GSK-3βc-Src和ras/raf/MAPK信号通路,介导细胞增殖和抑制细胞凋亡，Cripto蛋白的单细胞繁殖抗体，可以有效抑制一些癌细胞的生长。
畸胎瘤衍化生长因子单克隆抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 细胞凋亡 生长因子和** 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Mouse
外观： Lyophilized or Liquid