巢蛋白/神经上皮干细胞蛋白抗体
规格：1mg/1ml
英文名： Nestin
别名： ESTM 46; FLJ 21841; FLJ21841; Intermediate filament protein; Nbla00170; Nes; NEST_HU
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Nestin
交叉反应：Human,
巢蛋白/神经上皮干细胞蛋白抗体细胞定位：
产品介绍：background: There are a certain number of neural stem cells, which can be potentially differentiated into the neurons or neuroglia, in the ***** mammalian brain. These neural precursors are located in the subependymal cell layer of the ventricle. Those precursors isolated from embryonic brain can be divided and differentiated into the neurons and glia in vitro and this is regulated by a series of growth-factor actions. Function: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor 巢蛋白/神经上皮干细胞蛋白抗体cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Subunit: Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, tis protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3 (By similarity). Tissue Specificity: CNS stem cells. Post-translational modifications: Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized. Similarity: Belongs to the intermediate filament family. 巢蛋白/神经上皮干细胞蛋白抗体Gene ID: 10763 Database links: Entrez Gene: 10763 Human Entrez Gene: 18008 Mouse Entrez Gene: 25491 Rat Omim: 600915 Human SwissProt: P48681 Human SwissProt: Q6P5H2 Mouse SwissProt: P21263 Rat Unigene: 527971 Human Unigene: 331129 Mouse Unigene: 9701 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 结构蛋白（Structural Proteins） Neural Stem Cell Marker (神经干细胞标志物) 在动物体早期发育过程中，**神经系统发育尤为重要 。Nestin是一种中等纤维蛋白，它在哺乳动物神经前体细胞中表达较高，目前已被广泛用于神经前体细胞的重要标志分子。研究Nestin的表达调控规律，将有助于人们认识神经前体细胞的生物特性。此抗体还表达**神经系统干细胞及神经上皮细胞。
巢蛋白/神经上皮干细胞蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 发育生物学 神经生物学 干细胞 细胞类型标志物 肿瘤细胞生物标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid