肾上腺髓质素抗体
规格：1mg/1ml
英文名： ADM
别名： Adrenomedullin; ADM; ADM precursor; ADML_HUMAN.
分子量： 20kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ADM N-te
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse,
肾上腺髓质素抗体细胞定位：分泌型蛋白
产品介绍：background: Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of4 exons and 3 introns,肾上腺髓质素抗体 with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. Function: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. 肾上腺髓质素抗体Subcellular Location: Secreted. Tissue Specificity: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues. Similarity: Belongs to the adrenomedullin family. Gene ID: 133 Database links: Entrez Gene: 133 Human NCBI: NP_001115 Human Omim: 103275 Human SwissProt: P35318 Human Unigene: 441047 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 肾上腺髓质素（Adrenomedullin， AM）是广泛分布在肾上腺髓质、肺、心、肝、肾等器官。
肾上腺髓质素抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 神经生物学 信号转导 细胞凋亡 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid