褪黑素受体1A/松果体素受体1A抗体
规格：1mg/1ml
英文名： Melatonin Receptor 1A
别名： Mel 1A R; Mel1a melatonin receptor; Mel1a receptor; MEL-1A-R; Melatonin receptor type 1A; MelR; MR; MT 1; MT1; MTNR 1A; MTNR1A; Melatonin receptor 1A; MTR1A_HUMAN; MTR-1A.
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from the midlle of
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, Guinea Pig,
褪黑素受体1A/松果体素受体1A抗体细胞定位：细胞膜
产品介绍：background: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. Function: High affinity receptor for melatonin. 褪黑素受体1A/松果体素受体1A抗体Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 4543 Database links: Entrez Gene: 4543 Human Omim: 600665 Human SwissProt: P48039 褪黑素受体1A/松果体素受体1A抗体Human Unigene: 243467 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 褪黑**受体1A- 此抗体是MTR-1A特异性抗体，与MTR-1B无交叉反应。MEL-1A-R除分布在视网膜和下丘脑外，还广泛存在于多个组织中，也是有重着要生理活性的**。
褪黑素受体1A/松果体素受体1A抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:10-100 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 细胞膜受体 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid