钙调磷酸酶A/钙依赖磷酸酶A抗
规格：1mg/1ml
英文名： PPP3CA
别名： Calcineurin A alpha; CalcineurinA; Calcineurin A; Calmodulin dependent calcineurin A subunit alpha isoform; CALN; CALNA 1; CALNA; CALNA1; CAM PRP catalytic subunit; CCN 1; CCN1; CNA 1; CNA; CNA1; PPP2
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PPP3CA
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
钙调磷酸酶A/钙依赖磷酸酶A抗细胞定位：细胞核
产品介绍：background: Calcineurin, a major soluble calmodulin binding protein in the brain, a Ca2+/calmodulin dependent serine/threonine protein phosphatase, with a relatively narrow substrate specificity. This metalloenzyme, also known as phosphatase 2B, is a heterodimer composed of a calmodulin binding, catalytic alpha subunit 61 kDa, calcineurin A) and calcium binding beta subunit (18 kDa, calcineurin B). The Ca2+ binding subunit, calcineurin B, is immunologically conserved from yeast to mammals. The presence of 2 different calcineurin B isoforms (beta 1 and beta 2) has been reported in rat testis. The catalytic subunit of calcineurin, calcineurin A, isolated from different tissues or different organisms, exhibits some immunological heterogeneity. Further, there are at least 2 isoforms of calcineurin A in bovine brain (alpha 1 and alpha 2,钙调磷酸酶A/钙依赖磷酸酶A抗 61 and 59 kDa, respectively). Function: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1. Subunit: Interacts with CHP1 and CHP2. Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. 钙调磷酸酶A/钙依赖磷酸酶A抗Interacts with CMYA5; this interaction represses calcineurin activity in muscle. Subcellular Location: Nucleus. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. Similarity: Belongs to the PPP phosphatase family. PP-2B subfamily. Gene ID: 5530 Database links: Entrez Gene: 5530 Human Entrez Gene: 19055 Mouse Entrez Gene: 24674 Rat Omim: 114105 Human SwissProt: Q08209 Human SwissProt: P63328 Mouse SwissProt: P63329 Rat Unigene: 435512 Human Unigene: 331389 Mouse Unigene: 6866 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 激酶和磷酸酶;蛋白磷酸酯酶-2B催化亚单位
钙调磷酸酶A/钙依赖磷酸酶A抗产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Mouse
外观： Lyophilized or Liquid
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