ChAT胆碱乙酰转移酶抗体
规格：1mg/1ml
英文名： ChAT
别名： Choline O acetyltransferase; Choline O acetyltransferase; Acetyl CoA choline O acetyltransferase; Acetyl CoA:choline O acetyltransferase; ChAT; CHOACTase; Choline acetylase; choline acetyltransferase;
分子量： 68-70kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ChAT
交叉反应：Human, Mouse, Rat, Dog, Pig,
ChAT胆碱乙酰转移酶抗体细胞定位：
产品介绍：background: The neurotransmitter acetycholine is synthesized from choline and acetyl-coA by the choline acetyltransferase (ChAT)enzyme,and a specific marker of cholinergic neurons.The regulation of ChATactivity is thought to be important during the development of nervous systems interactions .The reduction of ChAT activity has been found in several neurodegenerative disorders including Alzheimer’s and amyotrophic lateral sclerosis. Function: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. DISEASE: Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile ChAT胆碱乙酰转移酶抗体myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Similarity: Belongs to the carnitine/choline acetyltransferase family. Gene ID: 1103 Database links: Entrez Gene: 1103 Human Entrez Gene: 12647 Mouse Entrez Gene: 290567 Rat Omim: 118490 Human SwissProt: P28329 Human SwissProt: Q03059 ChAT胆碱乙酰转移酶抗体Mouse SwissProt: P32738 Rat Unigene: 302002 Human Unigene: 442817 Mouse Unigene: 45116 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胆碱乙酰转移酶是一种在神经元胞体内合成的酶。当该转移酶被合成以后，通过轴质流动方式转移到神经轴突末端。其功能是将乙酰辅酶A转移到胆碱上，导致神经递质乙酰胆碱的形成。胆碱能系统参与多种神经功能。一些胆碱能神经元的改变能导致阿尔茨海默病的发生。 胆碱乙酰转移酶通常被用来标记神经元。
ChAT胆碱乙酰转移酶抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid