Caspase 激活的脱氧核糖核酸酶抗体
规格：1mg/1ml
英文名： DFFB
别名： 5730477D02Rik; CAD; Caldesmon; Caspase activated deoxyribonuclease; Caspase activated DNase; Caspase activated nuclease; Caspase-activated deoxyribonuclease; Caspase-activated DNase; Caspase-activated
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse DFF-40 b
交叉反应：Mouse, Rat, Rabbit, Guinea Pig,
Caspase 激活的脱氧核糖核酸酶抗体细胞定位：细胞核 细胞浆
产品介绍：background: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments ofCaspase 激活的脱氧核糖核酸酶抗体 DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq, Jul 2008]. Function: Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. Subunit: Heterodimer of DFFA and DFFB Subcellular Location: Cytoplasm. Nucleus. Similarity: Contains 1 CIDE-N domain. Gene ID: 13368 Database links: Entrez Gene: 1677 Human Entrez Gene: Caspase 激活的脱氧核糖核酸酶抗体13368 Mouse Entrez Gene: 84359 Rat Omim: 601883 Human SwissProt: O76075 Human SwissProt: O54788 Mouse SwissProt: Q99N34 Rat Unigene: 133089 Human Unigene: 388918 Mouse Unigene: 67077 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Caspase 激活的脱氧核糖核酸酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 细胞凋亡 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid