脑钠素/利钠肽抗体
规格：1mg/1ml
英文名： BNP
别名： BNP 32; Brain natriuretic peptide 32; Gamma brain natriuretic peptide; Natriuretic peptide brain type; Natriuretic peptide precursor B; Natriuretic peptides B; NPPB; NPPB protein; ANFB_HUMAN; Natriure
分子量： 3.5kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BNP 32 (
交叉反应：Human,
脑钠素/利钠肽抗体细胞定位：分泌型蛋白
产品介绍：background: Brain natriuretic peptide (BNP) circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. BNP is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. BNP belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic peptides (eleven of the 17 amino acid residues are homologous in the ring of each of the natriuretic peptides). BNP is a 32 amino acid peptide with disulfide bond between the cysteine residues Cys10 and Cys26. 脑钠素/利钠肽抗体In earlier studies it has been demonstrated that BNP concentration in blood increases with the severity of congestive heart failure. Quantitative measurement of BNP in blood provides an objective indicator of congestive heart failure severity Function: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Subcellular Location: Secreted. Tissue Specificity: Brain and also in atria, but at much lower levels than ANP. Similarity: Belongs to the natriuretic peptide family. Gene ID: 4879 Database links: Entrez Gene: 4879 Human Omim: 600295 Human SwissProt: P16860 Human Unigene: 脑钠素/利钠肽抗体219140 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 脑钠素主要是心脏**，心脏作为***器官释放脑钠素，调解体液及电解质内环境的恒定性。 B型利钠肽（钠尿肽）（B－typenatriureticpeptide，BNP），又称脑钠素或脑钠肽，因其有排钠**、内皮非依赖性的血管平滑肌作用而具有降压、抗心肌纤维化、影响神经***系统等功效。 近来发现BNP在各种心血管**，尤其是心室功能不全、急性心肌梗死（ami）、高血压等**的诊断、**及预后等方面有重要意义，已引起临床工作者的高度重视。
脑钠素/利钠肽抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 信号转导 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid