血管紧张素原抗体
规格：1mg/1ml
英文名： AGT
别名： Angiotenogen; Angiotensinogen; AT; ANGT_HUMAN; Serpin A8.
分子量： 49kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human AGT N-te
交叉反应：Human, Mouse, Rat,
血管紧张素原抗体细胞定位：分泌型蛋白
产品介绍：background: Angiotensinogen protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Function: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).血管紧张素原抗体 Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3 stimulates aldosterone release. Subunit: During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg. Subcellular Location: Secreted. Tissue Specificity: Expressed by the liver and secreted in plasma. DISEASE: Genetic variations in AGT are a cause of susceptibility to essential hypertension (EHT) [MIM:145500]. Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause. Defects in AGT are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is血管紧张素原抗体 an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Similarity: Belongs to the serpin family. Gene ID: 183 Database links: Entrez Gene: 183 Human Entrez Gene: 11606 Mouse Entrez Gene: 24179 Rat Omim: 106150 Human SwissProt: P01019 Human SwissProt: P11859 Mouse SwissProt: P01015 Rat Unigene: 19383 Human Unigene: 301626 Mouse Unigene: 6319 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 血管紧张素原（Angiotenogen, AT）是一种大分子糖蛋白和α2球蛋白广泛分布于血液循环、**、脑、肾脏等组织。
血管紧张素原抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Mouse
外观： Lyophilized or Liquid