卵巢癌抗原抗体
规格：1mg/1ml
英文名： CA125
别名： CA 125; CA125; CA-125; CA125 ovarian cancer antigen; Cancer antigen 125; FLJ14303; MUC16_HUMAN; MUC 16; MUC16; Mucin 16; MUC-16; Mucin 16 cell surface associated; Mucin16; Ovarian cancer related tumor
分子量： 200kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CA125
交叉反应：Human,
卵巢癌抗原抗体细胞定位：细胞膜 分泌型蛋白
产品介绍：background: MUC16 (CA125) is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is overexpressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16 is a high molecular mass glycoprotein, although estimates of its size range from 200 to 2000 kDa with smaller “subunits” being described by some investigators. Function: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Subunit: Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via 卵巢癌抗原抗体binding to MSLN. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain. Tissue Specificity: Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. Post-translational modifications: Heavily O-glycosylated; expresses both type 1 and type 2 core glycans. Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans. May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the 卵巢癌抗原抗体lumen of secretory ducts. Similarity: Contains 2 ANK repeats. Contains 56 SEA domains. Gene ID: 94025 Database links: Entrez Gene: 94025 Human SwissProt: Q8WXI7 Human Unigene: 432676 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CA125是与卵巢癌细胞相关的膜表面糖蛋白。在正常情况下卵巢细胞中无CA125抗原，但在经期和孕期妇女的卵巢中发现存在由此种抗原。 该蛋白是上皮性卵巢癌尤其是浆液性腺癌的主要标记，也可用于其他恶性肿瘤的研究，如：乳腺癌、胰腺癌、肝癌和消化系统的肿瘤等。
卵巢癌抗原抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导 细胞类型标志物 细胞骨架 肿瘤细胞生物标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid