肿瘤坏死因子β抗体
规格：1mg/1ml
英文名： TNF beta
别名： TNF-beta; TNF beta; LTalpha; Coley’s toxin; DIF; Differentiation inducing factor; Hemorrhagic factor; LT alpha; LT; LTA; LTalpha; Lymphotoxin alpha (TNF superfamily, member 1); Lymphotoxin alpha; Natu
分子量： 18kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TNF beta
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
肿瘤坏死因子β抗体细胞定位：细胞膜 分泌型蛋白
产品介绍：background: Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Gene Symbol: TNF-Beta; tumor necrosis factor-Beta; Tumor necrosis factor ligand superfamily member 1; TNFSF1; LTA; Lymphotoxin-alpha; TNF-beta; LT-alpha. Function: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. Subunit: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or 肿瘤坏死因子β抗体(less prevalent) two LTA and one LTB subunits. Subcellular Location: Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated. DISEASE: Genetic variations in LTA are associated with susceptibility to leprosy type 4 (LPRS4) [MIM:610988]; also known as susceptibility to age-dependent leprosy. Leprosy is a chronic infectious disease of peripheral sensory nerves caused by Mycobacterium leprae. Genetic variations in LTA are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis. Similarity: Belongs to the tumor necrosis factor family. Gene ID: 4049 Database links: Entrez Gene:肿瘤坏死因子β抗体 4049 Human Entrez Gene: 16992 Mouse Entrez Gene: 25008 Rat Omim: 153440 Human SwissProt: P01374 Human SwissProt: P09225 Mouse SwissProt: Q06332 Rat Unigene: 36 Human Unigene: 87787 Mouse Unigene: 160577 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 生长因子和** 肿瘤坏死因子-β（TNF β）是多功能细胞因子，又称****(Lymphotoxin,LT)是由活化**细胞所产生，它具有抗肿瘤、抗病毒、诱导成纤维细胞、B细胞和胸腺细胞的增殖、分化以及调节**功能等广泛的生物学效应。
肿瘤坏死因子β抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid