α-1抗胰糜蛋白酶/SERPINA3抗体
规格：1mg/1ml
英文名： Alpha-1-Antichymotrypsin
别名： Alpha-1-Antichymotrypsin; AACT-Alpha 1; AACT Alpha 1; SERPINA3; AACT; A1ACT; ACT; Alpha 1 Antichymotrypsin 1; Alpha 1 Antichymotrypsin 2; Alpha 1 Antichymotrypsin 3; Alpha 1 Antitrypsin Deficiency; An
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human AACT-Alp
交叉反应：Human,
α-1抗胰糜蛋白酶/SERPINA3抗体细胞定位：分泌型蛋白
产品介绍：background: Alpha 1-Antichymotrypsin, a member of the serine proteinase inhibitor (serpin) family, inhibits neutrophil proteinase cathepsin G and mast cell chymases, and protects the lower respiratory tract from damage by proteolytic enzymes. It contains a reactive centre loop, which interacts with cognate proteinases, resulting in loop cleavage and a major conformational change. Recently, alpha 1-antichymotrypsin has been identified as a major constituent of the neurofibrillary plaques associated with Alzheimers disease, and in vitro studies have shown that it enhances the rate of amyloid-fibril formation. These observations and recent genetic evidence suggest that alpha 1-antichymotrypsin is important in the pathogenesis of Alzheimers disease. Function: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, α-1抗胰糜蛋白酶/SERPINA3抗体both of which can convert angiotensin-1 to the active angiotensin-2. Subunit: Interacts with DNAJC1. Subcellular Location: Secreted. Tissue Specificity: Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. Similarity: Belongs to the serpin family. Gene ID: 12 Database links: Entrez Gene: 12 Human Omim: 107280 Human SwissProt: P01011 Human Unigene: 534293 Human Unigene: 710488 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. α-1抗胰糜蛋白酶/SERPINA3抗体AACT是由神经胶质细胞分泌并参与淀粉样纤维生成和沉积的一种色氨酸蛋白酶抑制剂,被认为是Aβ肽的假性底物，与Aβ肽具有很高的亲合性，可促进Aβ肽的纤维化以生成淀粉样沉积。 ApoE作为AD的另一种病理伴随性物质，也可识别并与Aβ肽相结合，促进Aβ肽沉积生成淀粉样老年斑块。由于AACT和ApoE在AD发病中具有共同的作用途径，因此探讨其相互作用可能是AD**中一个新的途径。 AACT是一种丝氨酸蛋白酶抑制剂，可以中和糜蛋白酶等酶活性的蛋白酶，存在于大多数的组织细胞、巨噬细胞以及多种胃肠道和肺部肿瘤中，但多形核白细胞中无此物质，它可以作为组织细胞瘤和良性/恶性纤维组织细胞瘤的标志。此抗体与人的AACT反应，主要用于恶性纤维组织细胞瘤等恶性肿瘤的诊断,也可用于胃癌﹑肺癌、肾癌等肿瘤的研究。
α-1抗胰糜蛋白酶/SERPINA3抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 神经生物学 糖尿病 泛素 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid