瘦素抗体
规格：1mg/1ml
英文名： Leptin
别名： LEP; Leptin Murine Obesity Homolog; Leptin Precursor Obesity Factor; OB; Obese Protein; Obesity; Obesity factor; Obesity homolog mouse; Obesity Murine Homolog Leptin; OBS; LEP_MOUSE.
分子量： 16kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse Leptin
交叉反应：Mouse, Rat, Dog, Pig, Cow, Horse,
瘦素抗体细胞定位：分泌型蛋白
产品介绍：background: This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]. Function: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy瘦素抗体 of the adipose mass. Subunit: Interacts with SIGLEC6. Subcellular Location: Secreted (Probable). DISEASE: Leptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the leptin family. Gene ID: 16846 Database links: Entrez Gene: 3952 Human Entrez Gene: 16846 Mouse Entrez Gene: 25608 Rat Omim: 164160 Human SwissProt: P41159 Human SwissProt: P41160 Mouse 瘦素抗体SwissProt: Q29406 Pig SwissProt: P50596 Rat SwissProt: Q28603 Sheep Unigene: 194236 Human Unigene: 277072 Mouse Unigene: 44444 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Leptin是一种分子量为16kDa的脂肪组织源**，又称：肥胖蛋白(Obese-protein)是由脂肪细胞分泌的，具有强亲水性，以单体形式存在于血浆中。 Leptin 具有广泛的生物学效应，作用于下丘脑，调节食欲、能量代谢及体重。Leptin 还可能作为脂肪-胰岛***轴的一部分，参与胰岛素分泌的调节。
瘦素抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 神经生物学 信号转导 干细胞 生长因子和** 糖尿病 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid