芳香化酶/细胞色素P450/雌**合成酶抗体
规格：1mg/1ml
英文名： Aromatase
别名： Cytochrome p450 19A1; Estrogen synthetase; ARO 1; ARO; ARO1; CPV; CYPXIX; Cytochrome P450 19A1; Cytochrome P450 family 19 subfamily A polypeptide 1; MGC104309; P 450AROM; P450AROM; CP19A_HUMAN; Cytoch
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Aromatas
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
芳香化酶/细胞色素P450/雌**合成酶抗体细胞定位：细胞膜
产品介绍：background: Aromatase is a key enzyme in steroidogenesis and plays an important role in sexual differentiation, oestrogen biosynthesis, fertility and carcinogenesis. It is highly conserved amongst mammals, and is highly expressed in placental tissue. Many environmental chemicals may influence aromatase activity and thereby disrupt endocrine function. Function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Subcellular Location: Membrane; Peripheral membrane protein. Tissue Specificity: Brain, placenta and gonads. DISEASE: Defects in CYP19A1 are a cause of aromatase excess syndrome (AEXS) [MIM:139300]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity. Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:613546].芳香化酶/细胞色素P450/雌**合成酶抗体 AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In ***** females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries. Similarity: Belongs to the cytochrome P450 family. Gene ID: 1588 Database links: Entrez Gene: 1588 Human Entrez Gene: 13075 Mouse Entrez Gene: 25147 Rat Omim: 107910 Human SwissProt: P11511 Human SwissProt: P28649 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 芳香化酶是一种微粒体酶系统，催化睾酮经三步连续强化转变成17-β-雌二醇,在反应中睾酮作为**原。 细胞色素P450主要分布在内质网和线粒体内膜上，作为一种末端加氧酶，参与了生物体内的甾醇类**合成等过程。 近年来，对细胞色素P450的结构、功能特别是对其在**代谢中的作用的研究有了较大的进展。 *新研究表明细胞色素P450还是**代谢过程中的关键酶，而且对细胞因子和体温调节都有重要影响。 芳香化酶-细胞色素P450作为和**代谢及细胞因子相关的重要酶类，芳香化酶/细胞色素P450/雌**合成酶抗体在**代谢和**中起着相当重要的作用，对于它的研究将有助于新药的开发，并能帮助人们更加清楚的认识**的代谢途径，在未来的新药中减少副作用，增加**疗效。随着对细胞色素P450研究的深入，将有更多相关的**代谢途径被发现，人们开发新药的视野将更加开阔，新药开发的速度也将加快，质量进一步提高。 鉴于P450的研究无论在理论上探索生物的生理代谢、选择进化和生物与环境的关系方面,或在环境保护、农业生态、生物防治、作物基因工程和医药卫生等应用方面,都有广泛的实践意义,因此,应该受到更大的关注和重视。
芳香化酶/细胞色素P450/雌**合成酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 细胞凋亡 合成与降解
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid