降钙素受体抗体
规格：1mg/1ml
英文名： Calcitonin receptor
别名： Calcitonin receptor precursor; Calcr; CRT; CT R; CTR; CTR1; CALCR_MOUSE; CT-R; CALCR_HUMAN.
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse Calciton
交叉反应：Mouse, Rat,
降钙素受体抗体细胞定位：细胞膜
产品介绍：background: This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] Function: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric降钙素受体抗体 guanosine triphosphate-binding protein that is sensitive to cholera toxin. Subunit: Interacts with GPRASP2. Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 2 family. Gene ID: 12311 Database links: Entrez Gene: 799 Human Entrez Gene: 12311 Mouse Entrez Gene: 116506 Rat Omim: 114131 Human SwissProt: P30988 Human SwissProt:降钙素受体抗体 Q60755 Mouse SwissProt: P32214 Rat Unigene: 489127 Human Unigene: 4642 Mouse Unigene: 10062 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 降钙素受体（Calcitonin receptor,CT-R)是G蛋白偶联受体，有两种受体亚型，CT-R可与多种配体结合，如CGRP、Amylin、Am等。CT-R在破骨细胞中含量*高，也存在于肾等多种器官组织内。
降钙素受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 神经生物学 信号转导 细胞膜受体 G蛋白偶联受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid