轴索过度生长抑制因子受体/Nogo受体抗体
规格：1mg/1ml
英文名： Nogo R
别名： NgR; Nogo-66 receptor; Nogor; NogoR; Nogo-R; Reticulon 4 receptor; Rtn4r; RTN4R_RAT.
分子量： 48kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse Nogo R
交叉反应：Mouse, Rat,
轴索过度生长抑制因子受体/Nogo受体抗体细胞定位：细胞膜
产品介绍：background: Axons are essential for neuronal communication but they do not regenerate after injury to the ***** mammalian brain or spinal cord. Failed regeneration is due in part to the production of a potent axonal growth inhibitor, Nogo, by myelinating cells. The finding of a high affinity axonal receptor for the extracellular domain of Nogo provides the first insight into the basis of Nogo action. Disrupting the interaction of Nogo with the Nogo-66 receptor may facilitate axonal regeneration in vivo. The protein is dubbed the Nogo receptor because it binds with several other proteins that block neural growth. It is found to be ubiquitous in the brain and spinal cord. Function: Receptor for RTN4, OMG and MAG.轴索过度生长抑制因子受体/Nogo受体抗体 Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the ***** central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity). Subunit: Homomultimer. Interacts with LINGO1. Interacts with KIAA0319L. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Similarity: Belongs to the Nogo receptor family. Contains 8 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT轴索过度生长抑制因子受体/Nogo受体抗体 domain. Gene ID: 65079 Database links: Entrez Gene: 65078 Human Entrez Gene: 65079 Mouse Entrez Gene: 113912 Rat Omim: 605566 Human SwissProt: Q9BZR6 Human SwissProt: Q99PI8 Mouse SwissProt: Q99M75 Rat Unigene: 30868 Human Unigene: 40149 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
轴索过度生长抑制因子受体/Nogo受体抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid