C-反应蛋白抗体
规格：1mg/1ml
英文名： CRP
别名： C-reactive protein; C Reactive Protein; C reactive protein pentraxin related; CRP; MGC88244; PTX 1; PTX1.
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CRP (151
交叉反应：Human, Mouse, Rat, Dog, Pig, Rabbit,
C-反应蛋白抗体细胞定位：分泌型蛋白
产品介绍：background: Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins,C-反应蛋白抗体 may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers. Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Subunit: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Subcellular Location: Secreted. Tissue Specificity: Found in plasma. Similarity: Belongs to the pentaxin family. Contains 1 pentaxin domain. Gene ID: 1401 Database links: Entrez Gene: C-反应蛋白抗体1401 Human Omim: 123260 Human SwissProt: P02741 Human Unigene: 76452 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. C反应蛋白 CRP（C-reactive protin）是与C性肺炎球菌的多糖起反应的一种蛋白，在某些**的感染过程中出现在血浆中。 CRP是在一些病理性情况下出现于病人血清中的一种糖蛋白，特别是在伴有肯炎症和组织坏死**的急性期。血清中出现的这种异常蛋白能和肺炎C-多糖体发生沉淀反应，当**好转或缓解时，CRP减低或消失。 临床意义: (1)各种急性化脓性炎症、菌血症、组织坏死(心肌梗塞、手术、严重创伤、**等)、恶性肿瘤、结缔组织病、肾移殖后急性排异反应、急性风湿热、风湿性关节炎、类风湿性关节炎、心肌炎急性期、肺炎、肺结核、系统性红斑狼疮、急性肝炎和阑尾炎等，血清中CRP含量可增高，它的出现比其它急性期的反应物质早，所以对**的早期诊断很有帮助。 CRP可以鉴别**炎症或者是病毒性炎症。**性炎症CRP可以明显增高，而病毒性炎症CRP的血清含量一般都在正常范围。
C-反应蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 **学 信号转导 细胞凋亡 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid