核受体相关因子-1抗体
规格：1mg/1ml
英文名： Nurr1
别名： Nur-ralated factor 1; Nuclear receptor-related factor 1; Orphan nuclear receptor NR4A2; Orphan nuclear receptor NURR1; Regenerating liver nuclear receptor 1; RNR-1; SL-322; Nuclear orphan receptor HZF
分子量： 67kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Nurr1
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit,
核受体相关因子-1抗体细胞定位：细胞核
产品介绍：background: Nuclear receptor and transcription factor; plays a role in development and maintenance of neurons synthesizing the neurotransmitter dopamine This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. 核受体相关因子-1抗体Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined. Function: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Subunit: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3 (By similarity). Subcellular Location: Nucleus. Tissue Specificity: Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily. 核受体相关因子-1抗体Contains 1 nuclear receptor DNA-binding domain. Gene ID: 4929 Database links: Entrez Gene: 4929 Human Entrez Gene: 18227 Mouse Entrez Gene: 54278 Rat Omim: 601828 Human SwissProt: P43354 Human SwissProt: Q06219 Mouse SwissProt: Q07917 Rat Unigene: 563344 Human Unigene: 3507 Mouse Unigene: 88129 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 该抗体和类固醇/甲状腺素受体密切相关的早期应急反应基因，也受各种生长因子的诱导。中脑多巴胺神经细胞和脑干细胞表达。
核受体相关因子-1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：染色质和核信号 神经生物学 新陈代谢 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid