多巴胺脱羧酶抗体
规格：1mg/1ml
英文名： DOPA Decarboxylase
别名： AADC; DDC; Aromatic L Amino Acid Decarboxylase; DDC protein; DOPA decarboxylase; aromatic-L-amino-acid decarboxylase isoform 1; DDC_HUMAN.
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DDC
交叉反应：Human, Mouse, Rat,
多巴胺脱羧酶抗体细胞定位：
产品介绍：background: DOPA decarboxylase is an enzyme implicated in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine and serotonin which both play key roles in many clinical disorders, including Parkinson's disease. Following the hydroxylation of tyrosine to form L dihydroxyphenylalanine (LDOPA), catalyzed by tyrosine hydroxylase, DDC decarboxylates LDOPA to form dopamine. This neurotransmitter is found in different areas of the brain and is particularly abundant in basal ganglia. Dopamine is also produced by DDC in the 多巴胺脱羧酶抗体sympathetic nervous system and is the precursor of the catecholaminergic hormones, noradrenaline and adrenaline in the adrenal medulla. In the nervous system, tryptophan hydroxylase produces 5 OH tryptophan, which is decarboxylated by DDC, giving rise to serotonin. DDC is a homodimeric, pyridoxal phosphate dependent enzyme. Function: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Subunit: Homodimer. DISEASE: Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, 多巴胺脱羧酶抗体gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive. Similarity: Belongs to the group II decarboxylase family. Gene ID: 1644 Database links: Entrez Gene: 1644 Human Entrez Gene: 13195 Mouse Entrez Gene: 24311 Rat Omim: 107930 Human SwissProt: P20711 Human SwissProt: O88533 Mouse SwissProt: P14173 Rat Unigene: 359698 Human Unigene: 12906 Mouse Unigene: 11064 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 该抗体主要用于：神经细胞退行性改变-老年滞呆的研究
多巴胺脱羧酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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