热休克蛋白-60/groEL抗体
规格：1mg/1ml
英文名： HSP60
别名： HSP 60; HSP-60; 60 kDa chaperonin;60 kDa heat shock protein mitochondrial; 60kDa; cb863; Chaperonin 60; Chaperonin;Chaperonin, 60-KD; CPN 60; CPN60; fa04a05; fb22d10;fi27b05; GROEL; GroEL Homolog; Gro
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HSP60 C-
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
热休克蛋白-60/groEL抗体细胞定位：
产品介绍：background: This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Two pseudogenes, both located on chromosome 8, have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. Function: Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. Subunit: Interacts with HRAS (By similarity). Interacts with HBV protein X and HTLV-1 protein p40tax. Interacts with ATAD3A. Subcellular Location: Mitochondrion matrix. DISEASE: Spastic paraplegia autosomal dominant 13 (SPG13) 热休克蛋白-60/groEL抗体[MIM:605280]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Note=The disease is caused by mutations affecting the gene represented in this entry. Leukodystrophy, hypomyelinating, 4 (HLD4) [MIM:612233]: A severe autosomal recessive hypomyelinating leukodystrophy. Clinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment热休克蛋白-60/groEL抗体, profound mental retardation. Death usually occurs within the first two decades of life. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the chaperonin (HSP60) family. Gene ID: 3329 Database links: Entrez Gene: 3329 Human Entrez Gene: 15510 Mouse Entrez Gene: 63868 Rat Omim: 118190 Human SwissProt: P86206 Hamster SwissProt: P10809 Human SwissProt: P63038 Mouse SwissProt: P63039 Rat Unigene: 595053 Human Unigene: 727543 Human Unigene: 1777 Mouse Unigene: 102058 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 信号传导（Signaling Intermediates） HSP60是一类进化上高度保守的蛋白质家族.生理状态时协助多肽或蛋白质的正确转位、折叠和装配,起"分子伴侣"的作用;在应激状态下,HSP60过表达或异位表达,作为一种自身抗原被**系统识别,诱发机体的保护性**应答,也可作为一种信号分子,在信号转导中发挥作用. 该蛋白与肿瘤的发生、增殖及分化有关，主要用于舌鳞癌、结肠癌、胰腺癌和乳腺癌的研究，近年来研究证实HSP60在自身**性**、传染病、动脉粥样硬化及慢性感染的发病中均发挥重要的作用。 HSP-60热休克蛋白-蛋白质折叠过程的引导因子 分子伴侣是一种引导蛋白质正确折叠的蛋白质。当蛋白质折叠时，它们能保护蛋白质分子免受其它蛋白质的干扰。很多分子伴侣属于热休克蛋白（例如HSP-60），它们在细胞受热时大量合成。热激可导致蛋白质稳定性降低，增加错误折叠的几率，因此在受到热刺激时，细胞中的蛋白质需要更多热休克蛋白的帮助。 HSP-60是一种典型的分子伴侣，它可以为正在折叠的蛋白质提供一个附着环境，从而起到保护折叠过程的作用。
热休克蛋白-60/groEL抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 转录调节因子 线粒体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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