血小板源性生长因子A抗体
规格：1mg/1ml
英文名： PDGF-A
别名： Platelet–dirived growth factor–1; PDGFA; PDGF AA; PDGF-AA; PDGF A chain; PDGF subunit A; PDGF-1; PDGF1; PDGFA; PDGFA_HUMAN; Platelet derived growth factor A chain precursor; Platelet derived growth fa
分子量： 14kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from the missle of
交叉反应：Human, Mouse, Rat, Rabbit,
血小板源性生长因子A抗体细胞定位：分泌型蛋白
产品介绍：background: Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heal the wound. Antiparallel disulfide-linked dimer of nonidentical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. The long form contains a basic insert which acts as a cell retention signal. A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor. It belongs to the PDGF/VEGF growth factor family. Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. 血小板源性生长因子A抗体Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. Subunit: Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4. Subcellular Location: Secreted. Note=Released by platelets upon wounding. Tissue Specificity: Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its receptor 血小板源性生长因子A抗体elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. Similarity: Belongs to the PDGF/VEGF growth factor family. Gene ID: 5154 Database links: Entrez Gene: 5154 Human Omim: 173430 Human SwissProt: P04085 Human Unigene: 535898 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PDGF-A（platelet-dirived growth factor-A）是一种碱性蛋白，pdgf促进细胞分裂、增值同时，可诱导c-fos、c-myc等蛋白表达增强。 主要作用：参与组织和血管修复、促进平滑肌细胞、成纤维细胞迅速增值。分子量为28-35kDa，分为两个亚基（A、B链）通过二硫键结合而成的两条多肽链的异二聚体。*新研究发现了PDGF家族两种新的基因PDGF-C、PDGF-D。
血小板源性生长因子A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 神经生物学 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid